The Spotlight Initiative implements a uniquely comprehensive approach to preventing violence against women and girls (VAWG). This comprehensive approach to prevention fosters gender equitable social norms, attitudes and behaviours and employs an all-of-society approach across the socio-ecological model to address the root cause of VAWG and underlying discriminatory gender norms. This brief surfaces overarching insights, drawing on analysis from a synthesis of 98 reports from 2019 to 2021 across all Spotlight Initiative country and regional programmes, trust funds, and global learning sessions. The Spotlight Initiative has garnered lessons including on the power of community education and knowledge to prevent VAWG and shift social norms, building community commitment, and scaling up efforts to prevent and end VAWG.